abstract：AIM:Assessment of the efficacy of vitamin D replenishment and maintenance doses required to attain optimal levels in boys with Duchenne muscular dystrophy (DMD). METHOD:25(OH)-vitamin D levels and concurrent vitamin D dosage were collected from retrospective case-note review of boys with DMD at the Dubowitz Neuromuscu...

journal_title：Archives of disease in childhood

authors： Alshaikh N,Brunklaus A,Davis T,Robb SA,Quinlivan R,Munot P,Sarkozy A,Muntoni F,Manzur AY,Dubowitz Neuromuscular Team.

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:The value of comparative effectiveness trials in informing clinical and policy decisions depends heavily on the choice of control arm (comparator). Our objective is to identify challenges in comparator reasoning and to determine justification criteria for selecting a control arm in paediatric clinical trials....

journal_title：Archives of disease in childhood

authors： Kelly LE,Davies EH,Saint-Raymond A,Tomasi P,Offringa M

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:To develop and validate a new allergy-specific patient-reported experience measure (PREM) for children and their parents, and to collect feedback in an integrated care setting. DESIGN:Two allergy-specific PREMs were produced using focus groups, cognitive testing, two prospective validation studies (collabor...

journal_title：Archives of disease in childhood

authors： Gore C,Griffin R,Rothenberg T,Tallett A,Hopwood B,Sizmur S,O'Keeffe C,Warner JO

更新日期：2016-10-01 00:00:00

abstract：AIM:Ketamine is used for post-operative analgesia. There has been recent disruption in it's supply. It is usually prescribed by patient's weight (3 mg/kg in 50 ml 0.9% saline) at a rate of 1-5 ml/hr (1-5 microgram/kg/minute). To conserve ketamine supplies our policy was changed to a concentrated "standardised" concentr...

journal_title：Archives of disease in childhood

authors： Wong J,Sutherland A

更新日期：2016-09-01 00:00:00

abstract：AIM:In paediatrics drugs are prescribed as mg/kg doses to facilitate accurate dosing. Anecdotally, some drugs are prescribed in such a way that the volume to be given is difficult to measure which may lead to inaccuracies and potential for error. Locally, errors have been reported where there has been a misunderstandin...

journal_title：Archives of disease in childhood

authors： Balsara J,Fletcher P

更新日期：2016-09-01 00:00:00

abstract：AIM:To determine the impact of displacement values on doses in paediatric patients when using parenteral. To assess the option of using average displacement values (DV) in the preparation of parenteral medicines. METHOD:Over 500 Medusa1 monographs were analysed and 42 medicines were identified with a displacement valu...

journal_title：Archives of disease in childhood

authors： Lo A,Christiansen N,Bhatti H

更新日期：2016-09-01 00:00:00

abstract：AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...

journal_title：Archives of disease in childhood

authors： Mott A,Kafka S,Sutherland A

更新日期：2016-09-01 00:00:00

abstract：AIM:To reduce the overall expenditure on melatonin for the local health economy by working collaboratively with the CCG's. To ensure that all paediatric patients prescribed melatonin have been clinically assessed by a specialist and the most appropriate formulation is dispensed. METHOD:Evaluation of GP melatonin presc...

journal_title：Archives of disease in childhood

authors： Haley H

更新日期：2016-09-01 00:00:00

abstract：AIM:To identify the experiences of patients, parents or carers when a child/young person is prescribed a new long-term medicine. METHOD:Patients' prescribed a new long-term (>6 weeks) medicine were recruited from a single UK paediatric hospital out-patient pharmacy.A semi-structured questionnaire was administered to p...

journal_title：Archives of disease in childhood

authors： Aston J,Wilson K,Terry D

更新日期：2016-09-01 00:00:00

abstract：AIM:To assess the time it takes for paediatric TTA and inpatient orders to be dispensed and sent to ward. This is to establish if the Trust is meeting an operational Key Performance Indicator (KPI). STANDARDS KPIS:▸ 85% of urgent items (TTAs) dispensed within 1 hour.▸ 85% of non-urgent items (most inpatient orders) di...

journal_title：Archives of disease in childhood

authors： Hale A,Christiansen N,Calvert H

更新日期：2016-09-01 00:00:00

abstract：SITUATION:Patient I is a 15 year old female with ornithine transcarbamylase deficiency prescribed L-arginine 1.5 g three times daily and sodium benzoate 4.2 g three times daily. By taking her medication and controlling her diet she is able to lead a normal life and does well at school. However she struggles with the pa...

journal_title：Archives of disease in childhood

authors： Gaskell C

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Intensive care patients are susceptible to developing painful corneal epithelial deficits. Provision of eye care to prevent deficits was limited in our paediatric intensive care unit (PICU) population. INTERVENTIONS:A new eye care bundle was introduced, comprising a guideline for eye care, the addition of e...

journal_title：Archives of disease in childhood

authors： McCall K,Hussin HM,Gregory ME,Dutton G,Richardson J

更新日期：2016-09-01 00:00:00

abstract：:Delayed puberty (DP) is defined as the lack of pubertal development by an age that is 2-2.5 SDs beyond the population mean. Although it generally represents a normal variant in pubertal timing, concern that DP could be the initial presentation of a serious underlying disorder has led to a diagnostic approach that is v...

journal_title：Archives of disease in childhood

authors： Abitbol L,Zborovski S,Palmert MR

更新日期：2016-08-01 00:00:00

abstract：:Safe and effective paediatric pharmacotherapy requires careful evaluation of the type of drug substance, the necessary dose and the age-appropriateness of the formulation. Generally, the younger the child, the more the attention that is required. For decades, there has been a general lack of (authorised) formulations ...

journal_title：Archives of disease in childhood

authors： van Riet-Nales DA,Schobben AF,Vromans H,Egberts TC,Rademaker CM

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Congenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life. METHODS:Twen...

journal_title：Archives of disease in childhood

authors： Hilland M,Røksund OD,Sandvik L,Haaland Ø,Aarstad HJ,Halvorsen T,Heimdal JH

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Risk assessment for venous thromboembolism (VTE) and thromboprophylaxis in those with risk factors is established in adult practice. Evidence to support efficacy and safety of this approach in adolescents is lacking. We aimed to describe thrombotic risk factors and to determine the proportion of potentially p...

journal_title：Archives of disease in childhood

authors： Biss T,Alikhan R,Payne J,Alamelu J,Williams M,Richards M,Mathias M,Tunstall O,Chalmers E

更新日期：2016-05-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) aims to integrate drug measurement results into clinical decision making. The basic rules apply when using TDM in neonates (aminoglycosides, vancomycin, phenobarbital, digoxin), but additional factors should also be taken into account. First, due to both pharmacokinetic variability an...

journal_title：Archives of disease in childhood

authors： Pauwels S,Allegaert K

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Short-course oral corticosteroids are commonly used in children but are known to be associated with adverse drug reactions (ADRs). This review aimed to identify the most common and serious ADRs and to determine their relative risk levels. METHODS:A literature search of EMBASE, MEDLINE, International Pharmac...

journal_title：Archives of disease in childhood

authors： Aljebab F,Choonara I,Conroy S

更新日期：2016-04-01 00:00:00

abstract：:Many children who present with these acquired impairments of communication have a clear preceding event such as an acquired brain injury from a road traffic accident. Children often respond differently in this situation to adult presentations. They may have a period of mutism when the prognosis might look poor and yet...

journal_title：Archives of disease in childhood

authors： O'Hare A

更新日期：2016-03-01 00:00:00

abstract：:Female genital mutilation (FGM) is almost always performed on children and consequently paediatricians should have a central role in the detection and prevention of FGM. FGM has no health benefits and can cause lifelong damage to physical and psychological health. Extensive migration of FGM practising communities mean...

journal_title：Archives of disease in childhood

authors： Creighton SM,Hodes D

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To undertake a systematic review and meta-analysis to establish the effectiveness of handwashing in reducing absence and/or the spread of respiratory tract (RT) and/or gastrointestinal (GI) infection among school-aged children and/or staff in educational settings. DESIGN:Randomised-controlled trials (RCTs). ...

journal_title：Archives of disease in childhood

authors： Willmott M,Nicholson A,Busse H,MacArthur GJ,Brookes S,Campbell R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year...

journal_title：Archives of disease in childhood

authors： Blumental S,Sabbe M,Lepage P,Belgian Group for Varicella.

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. DESIGN:Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empi...

journal_title：Archives of disease in childhood

authors： Spyridis N,Syridou G,Goossens H,Versporten A,Kopsidas J,Kourlaba G,Bielicki J,Drapier N,Zaoutis T,Tsolia M,Sharland M,ARPEC Project Group Members.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The number of children admitted to hospital is increasing year on year, with very short-stay admissions doubling in the last decade. Childhood head injury accounts for half a million emergency department attendances in the UK every year. The National Institute for Health and Care Excellence (NICE) has issued...

journal_title：Archives of disease in childhood

authors： Marlow R,Mytton J,Maconochie IK,Taylor H,Lyttle MD

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To describe the pathways by which children with cancer present to a shared care oncology unit. DESIGN:A population-based retrospective cohort study of children diagnosed with cancer between the years 2004 and 2014. SETTING:District General Hospital with a level 2 Paediatric Oncology Shared Care Unit. PATIE...

journal_title：Archives of disease in childhood

authors： Roskin J,Diviney J,Nanduri V

更新日期：2015-12-01 00:00:00

abstract：:Imaging has many uses, but in cases of suspected child abuse, radiographs and CT scans are vital in identifying fractures and head injury that may not be clinically obvious. There are growing concerns about the small but potential adverse effects of radiation, including cancer, in the paediatric population as a result...

journal_title：Archives of disease in childhood

authors： Bajaj M,Offiah AC

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Neonatal autosomal-recessive polycystic kidney disease (ARPKD) is associated with pulmonary hypoplasia and severe respiratory distress. There is no published information on long-term lung function in ARPKD survivors. METHODS:Pulmonary function tests, including spirometry and diffusion capacity, were perform...

journal_title：Archives of disease in childhood

authors： Jahnukainen T,Kirjavainen T,Luoto T,Ylinen E,Linkosalo L,Arikoski P,Pakarinen M,Jalanko H

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Moderately preterm children (gestational age 32-36+6 weeks) are at risk of cognitive and behaviour problems at school age. The aim of this study was to investigate if these problems are already present at the age of 2 years. STUDY DESIGN:Developmental outcome was assessed at 24-months (corrected age) with th...

journal_title：Archives of disease in childhood

authors： de Jong M,Verhoeven M,Lasham CA,Meijssen CB,van Baar AL

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To compare a comprehensive lifestyle intervention for overweight children performed in groups of families with a conventional single-family treatment. Two-year follow-up data on anthropometric and psychological outcome are presented. DESIGN:Overweight and obese children aged 6-12 years with body mass index (...

journal_title：Archives of disease in childhood

authors： Kokkvoll A,Grimsgaard S,Steinsbekk S,Flægstad T,Njølstad I

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the outcome of percutaneous transluminal angioplasty (PTA) in children with renovascular hypertension (RVH) treated at a single centre over 29 years. METHODS:A retrospective study of the medical charts of all children with RVH who underwent PTA between 1984 and 2012. The primary outcome measurem...

journal_title：Archives of disease in childhood

authors： Kari JA,Roebuck DJ,McLaren CA,Davis M,Dillon MJ,Hamilton G,Shroff R,Marks SD,Tullus K

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To study the temporal relationship between socioeconomic disadvantage and onset of chronic disabling conditions in childhood. METHOD:Using parent reported data from the Longitudinal Study of Australian Children, we compared children who developed a chronic disabling condition between the ages of 6/7 and 10/1...

journal_title：Archives of disease in childhood

authors： Spencer N,Strazdins L

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Silver-Russell syndrome (SRS) is an imprinted disorder characterised by intrauterine growth retardation, relative macrocephaly, failure to thrive, typical facial phenotype and frequent body asymmetry. Feeding difficulties are frequently noted, but no study described evolution of gastrointestinal signs during...

journal_title：Archives of disease in childhood

authors： Marsaud C,Rossignol S,Tounian P,Netchine I,Dubern B

更新日期：2015-04-01 00:00:00

abstract：RATIONALE:Studies suggest that increased breastfeeding rates can provide substantial financial savings, but the scale of such savings in the UK is not known. OBJECTIVE:To calculate potential cost savings attributable to increases in breastfeeding rates from the National Health Service perspective. DESIGN AND SETTINGS...

journal_title：Archives of disease in childhood

authors： Pokhrel S,Quigley MA,Fox-Rushby J,McCormick F,Williams A,Trueman P,Dodds R,Renfrew MJ

更新日期：2015-04-01 00:00:00

abstract：:Kwashiorkor and marasmus, collectively termed severe acute malnutrition (SAM), account for at least 10% of all deaths among children under 5 years of age worldwide, virtually all of them in low-income and middle-income countries. A number of risk factors, including seasonal food insecurity, environmental enteropathy, ...

journal_title：Archives of disease in childhood

authors： Trehan I,Manary MJ

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To quantify the burden of selected congenital anomalies in low and middle-income countries (LMICs) that could be reduced should surgical programmes cover the entire population with access to quality care. DESIGN:Burden of disease and epidemiological modelling. SETTING:LMICs from all global regions. POPULAT...

journal_title：Archives of disease in childhood

authors： Higashi H,Barendregt JJ,Kassebaum NJ,Weiser TG,Bickler SW,Vos T

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To determine which antenatal and early-life factors were associated with infant postnatal growth in a resource-poor setting in Vietnam. STUDY DESIGN:Prospective longitudinal study following infants (n=1046) born to women who had previously participated in a cluster randomised trial of micronutrient supplemen...

journal_title：Archives of disease in childhood

authors： Hanieh S,Ha TT,De Livera AM,Simpson JA,Thuy TT,Khuong NC,Thoang DD,Tran TD,Tuan T,Fisher J,Biggs BA

更新日期：2015-02-01 00:00:00

abstract：:Remarkable advances have been made over the past decade in defining the burden of newborn mortality and morbidity and stillbirths, and in identifying interventions to address the major risk factors and causes of deaths. However, progress in saving newborn lives and preventing stillbirths in countries lags behind that ...

journal_title：Archives of disease in childhood

authors： Darmstadt GL,Shiffman J,Lawn JE

更新日期：2015-02-01 00:00:00

abstract：:Malaria, as a key disease of poverty, was singled out for special attention in the Millennium Project of 2000. Recent data suggest that malaria incidence and mortality are now declining all over the world. While these figures are cause for celebration, they must be interpreted carefully and with caution, particularly ...

journal_title：Archives of disease in childhood

authors： Owens S

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To determine if exploratory factor analysis can identify subtypes comprising recognisable clinical patterns of the presenting signs and symptoms of children with joint hypermobility syndrome (JHS). PATIENTS:Eighty-nine children with JHS aged 6-16 years. METHODS:Twelve tests comprising anthropometric, muscul...

journal_title：Archives of disease in childhood

authors： Pacey V,Adams RD,Tofts L,Munns CF,Nicholson LL

更新日期：2015-01-01 00:00:00

abstract：:The term Ehlers-Danlos syndrome (EDS) encompasses a group of inherited connective tissue disorders. The manifestations of EDS can be seen in skin, joints, blood vessels and internal organs and vary from mild to severe and life threatening. Each subtype is a separate and different condition. The genetic basis of many s...

journal_title：Archives of disease in childhood

authors： Sobey G

更新日期：2015-01-01 00:00:00